Lunar New Year celebrants get no rest after Western holidays









At her store in Chinatown, Tracy Tieu replaces red and green Christmas trinkets with red and gold Lunar New Year decorations as she greets shoppers fresh from Las Vegas.


A mother strokes a jade dragon leaping from a dark wood emblem. A man and his wife unfurl scrolls bearing symbols of wealth. A student buys assorted little Buddhas, lining them up by belly size.


Inside the shop, Wing Ha Hing Gifts & Arts, Asian travelers this past weekend talk about how many aunts, uncles, cousins and grandparents they expect to host at noisy family gatherings.





One new year celebration may have ended — but for many Southern Californians the bustle of preparing for the Lunar New Year continues full force, with no time for holiday fatigue.


"We can't afford it," Tieu says. "We go with the season.... I order supplies six months in advance."


At crowded shopping plazas in Los Angeles' Chinatown and Koreatown, the San Gabriel Valley and Orange County's Little Saigon, seasonal foods line bakery shelves, holiday music plays on open-air speakers and Chinese, Korean and Vietnamese consumers are spending big — yet again — on their most important annual celebration.


The Year of the Snake begins Feb. 10. Those born under this sign are believed to have a good temper and strong passion, but can be suspicious.


The Lunar New Year is a time when debts are paid, arguments are laid to rest, hair is cut and homes are painted and polished and rituals are followed to sweep away ill fortune and welcome good luck. Doors and windows are decorated with themed images of happiness, prosperity and longevity, and incense is lighted in temples to pay respect to ancestors.


In the narrow, colorful shop her father opened in 1990, Tieu is surrounded by flowers, feng shui diaries, floating lotus candles and other traditional gifts.


Regina Gomez, a Chinese American from Nevada, was one of those hunting for bargains along Chinatown's main drag Sunday. She stopped at Tieu's store to prepare for the coming festivities. "When we buy for entertainment, it's better to buy for it here. It's less," she says, browsing with her kids, Shelby and Brittany. "I came to L.A. for Christmas and knew I should take a look before going home."


On the first morning of the new year, as everyone exchanges gifts and good wishes, Tieu plans to pass out crisp dollar bills in lucky red envelopes to some 20 nieces and nephews. "I have to give each of them at least $20 – anything smaller just isn't acceptable."


"It doesn't matter what we do or how much we gave for the previous holidays," adds Angie Tieu, her younger sister. "We have to remember the Lunar New Year, it's tradition, and we must spend."


On top of the financial costs, the extended holiday season carries health costs, said Calvin Ho, founder of the Plaid Bag Connection, a blog exploring the links between Asian groups outside their ethnic homeland. "We've been eating since the Moon Festival" in September "to Halloween, to Thanksgiving to Christmas and forward. Everyone overindulges because it's impossible not to."


Ho, who doesn't eat fried foods, says "with the holidays it's really hard to avoid it."


"Everything involves family," he said. "And when you are making multiple visits to different members of family day after day, you must sit down and share a meal. I get all my cravings in and it'll last until next fall."


Visiting Chinatown with her husband on Sunday, Elisa Aquino, who is half-Chinese, said she intends to serve dim sum dishes when she invites friends and relatives to her Carson home. "We go for a bang. High impact, lots of songs, lots of jokes.... I'm not cooking. We order," she adds.


Stephanie Yuan, working a souvenir kiosk nearby, said sales are brisk post-Christmas. "We are sold out of snake lucky charms," she says proudly, noting that the item features the animal highlighted in the 2013 Chinese zodiac.


"Here, you buy this one," she tells passing tourists, pointing to an Asian version of the Cheshire cat, complete with battery-operated paw, happy face and money pouch. On its white ceramic body is the Chinese character for $1 million. "It will lead you to a good way."


Merchants like Yuan and Thanh Ly, of neighboring Tambaba Fashion, can't take Lunar New Year off. "It's the day to sell," Ly says, folding traditional dresses made in Vietnam and Hong Kong. "We would like to have a vacation but we think about our living first. Some people buy last-minute."


Kevin Vong of Fresno isn't one of those. Outside Lien Hoa BBQ, he loads his truck with a whole roast pig, costing $195, carting it to a gathering to pray for the souls of his ancestors. He does this at the end of the Western new year, then again at the Lunar New Year. "I do not forget," he says. "I want someone doing that for me later. Years later."


anh.do@latimes.com





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Zynga carries out planned games shutdown, including “Petville”






SAN FRANCISCO (Reuters) – Social games publisher Zynga Inc confirmed on Monday that it has carried out 11 of the planned shutdowns of 13 game titles, with “Petville” being the latest game on which it pulled the plug.


Zynga in October said it would shut down 13 underperforming titles after warning that its revenues were slowing as gamers fled from its once-popular titles published on the Facebook platform in large numbers and sharply revised its full-year outlook.






The San Francisco-based company announced the “Petville” shutdown two weeks ago on its Facebook page. All the 11 shutdowns occurred in December.


The 11 titles shut down or closed to new players include role-playing game “Mafia Wars 2,” “Vampire Wars,” “ForestVille” and “FishVille.”


“In place of ‘PetVille,’ we encourage you to play other Zynga games like ‘Castleville,’ ‘Chefville,’ ‘Farmville 2,’ ‘Mafia Wars’ and ‘Yoville,’” the company told players on its ‘PetVille’ Facebook page. “PetVille” players were offered a one-time, complimentary bonus package for virtual goods in those games.


“Petville,” which lets users adopt virtual pets, has 7.5 million likes on Facebook but only 60,000 daily active users, according to AppData. About 1,260 users commented on the game’s Facebook page, some lamenting the game’s shutdown.


Zynga has said it is shifting focus to capture growth in mobile games. It also applied this month for a preliminary application to run real-money gambling games in Nevada.


Zynga is hoping that a lucrative real-money market could make up for declining revenue from games like “FarmVille” and other fading titles that still generate the bulk of its sales.


Zynga shares were up 1 percent at $ 2.36 in afternoon trade on Monday on the Nasdaq.


(Reporting By Malathi Nayak; Editing by Leslie Adler)


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Willard completes program, avoids lewdness charge


LOS ANGELES (AP) — Actor Fred Willard has completed a diversion program for his arrest this summer for a suspected lewd act at a Hollywood adult theater.


Frank Mateljan, a spokesman for the Los Angeles city attorney's office, said Monday that the 72-year-old comic actor completed the program in September and as a result no longer faces charges stemming from the July 18 incident.


Willard was arrested after uniformed vice officers were conducting a routine investigation of the theater and they said they saw him engaging in a lewd act.


He was fired shortly thereafter from his job narrating "Market Warriors," which is produced by Boston public television station WGBH. His film credits include "Best in Show" and "Waiting for Guffman."


An email message left for Willard's agent, Mike Eisenstadt, was not immediately returned.


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F.D.A. Approves Sirturo, a New Tuberculosis Drug





The Food and Drug Administration announced on Monday that it had approved a new treatment for multidrug-resistant tuberculosis that can be used as an alternative when other drugs fail.




The drug, to be called Sirturo, was discovered by scientists at Janssen, the pharmaceuticals unit of Johnson & Johnson, and is the first in a new class of drugs that aims to treat the drug-resistant strain of the disease.


Tuberculosis is a highly infectious disease that is transmitted through the air and usually affects the lungs but can also affect other parts of the body, including the brain and kidneys. It is considered one of the world’s most serious public health threats. Although rare in the United States, multidrug-resistant tuberculosis is a growing problem elsewhere in the world, especially in poorer countries. About 12 million people worldwide had tuberculosis in 2011, according to Johnson & Johnson, and about 630,000 had multidrug-resistant TB.


A study in September in The Lancet found that almost 44 percent of patients with tuberculosis in countries like Russia, Peru and Thailand showed resistance to at least one second-line drug, or a medicine used after another drug had already failed.


Treating drug-resistant tuberculosis can take years and can cost 200 times as much as treating the ordinary form of the disease


“This is quite a milestone in the story of therapy for TB,” Dr. Paul Stoffels, the chief scientific officer at Johnson & Johnson, said in an interview. He said the approval was the first time in 40 years that the agency had approved a drug that attacked tuberculosis in a different way from the current treatments on the market. Sirturo works by inhibiting an enzyme needed by the tuberculosis bacteria to replicate and spread throughout the body.


Sirturo, also known as bedaquiline, would be used on top of the standard treatment, which is a combination of several drugs. Patients with drug-resistant tuberculosis often must be treated for 18 to 24 months.


Even as it announced the approval, however, the F.D.A. also issued some words of caution.


“Multidrug-resistant tuberculosis poses a serious health threat throughout the world, and Sirturo provides much-needed treatment for patients who have don’t have other therapeutic options available,” Edward Cox, director of the office of antimicrobial products in the F.D.A.’s center for drug evaluation and research, said in a statement. “However, because the drug also carries some significant risks, doctors should make sure they use it appropriately and only in patients who don’t have other treatment options.”


The consumer advocacy group Public Citizen opposed approval in a letter to the F.D.A. in mid-December, saying that the results of a limited clinical trial showed that patients using bedaquiline were five times as likely to die than those on the standard drug regimen to treat the disease.


“Given that bedaquiline belongs to an entirely new class of drugs, it is entirely feasible that death in some cases was due to some unmeasured toxicity of the drug,” the letter said.


Sirturo carries a so-called black box warning for patients and health care professionals that the drug can affect the heart’s electrical activity, which could lead to an abnormal and potentially fatal heart rhythm. The warning also notes deaths in patients treated with Sirturo. Nine patients who received Sirturo died compared with two patients who received a placebo. Five of the deaths in the Sirturo group and all of the deaths in the placebo arm seemed to be related to tuberculosis, but no consistent reason for the deaths in the remaining Sirturo-treated patients could be identified.


Doctors Without Borders and the Bill and Melinda Gates Foundation, both active in the fight against tuberculosis and other global diseases, applauded the F.D.A.’s decision.


Jan Gheuens, interim director of the TB Program for the Gates Foundation, called it a “long-awaited event” and said the fight against TB had not benefited from new drugs in the way H.I.V. had. Beyond the benefits of the drug itself, he said the quick approval process could be a model for other drugs sorely needed in the developing world.


He also suggested, however, that more trials should be conducted to get a better understanding of the side effects that led to the black box warning.


The F.D.A. approved bedaquiline under an accelerated program that allows the agency to conditionally approve drugs that are viewed as filling unmet medical needs with less than the usual evidence that they work. The drug’s approval was based on studies that showed it killed bacteria more quickly than a control group taking the standard regimen, but it did not measure whether in the end patients actually fared better on bedaquiline. Johnson & Johnson will conduct larger clinical trials to investigate whether the drug performs as predicted.


In a statement responding to Public Citizen’s letter, a spokeswoman for Johnson & Johnson said the company was committed to supporting appropriate use of Sirturo and would “work to ensure Sirturo is used only where treatment alternatives are not available.”


Dr. Stoffels said the hope was that other new tuberculosis drugs would also be approved that, when used in combination with bedaquiline, could shorten and simplify the current standard of treatment. “That is still a long time away,” he acknowledged, but “this is a first step in a new regimen for TB.”


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Hobby Lobby to defy law on contraception insurance coverage









After losing a last-minute appeal to the Supreme Court, craft stores chain Hobby Lobby said it would defy a federal healthcare mandate requiring employers to provide their workers with insurance that covers emergency contraceptives.


The Oklahoma City-based chain, owned by a conservative Christian family, had applied to the high court to block a part of the federal healthcare law ordering companies to offer insurance that covers contraceptive drugs, including the so-called morning-after pill.


After the court refused to block the mandate, a lawyer for Hobby Lobby said the Green family, which also has holdings in Mardel Inc., a seller of religious books, would nonetheless refuse to provide health coverage for contraception it considers to be abortion-inducing.





Hobby Lobby and Mardel could be fined as much as $1.3 million a day starting Tuesday.


"They're not going to comply with the mandate," said Kyle Duncan, general counsel of the Becket Fund for Religious Liberty, which represents Hobby Lobby. "They're not going to offer coverage for abortion-inducing drugs in the insurance plan."


His comments were issued in a statement.


In the lawsuit, the Green family said certain types of contraception, such as the morning-after pill and the week-after pill, violated family members' religious beliefs against abortion.


The morning-after pill has spurred heated debate, especially among politicians, on whether using it constitutes abortion. The National Institutes of Health says on its website that the pills most likely work by preventing pregnancy "in the same way as regular birth control pills."


shan.li@latimes.com





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Hillary Clinton hospitalized with blood clot after concussion









WASHINGTON -- Secretary of State Hillary Rodham Clinton was hospitalized in New York on Sunday after doctors discovered a blood clot stemming from her concussion, the State Department said.


Clinton, 65, has been out of the public eye for the better part of December, at first because of what the State Department said was a stomach virus and later because of the concussion, which she suffered after fainting at her Washington home.


According to a spokesman, the clot was discovered in the course of a follow-up exam for the concussion at New York Presbyterian Hospital. She is being treated with anticoagulants and will remain at the hospital for the next 48 hours so doctors can monitor her response to the medication.





“Her doctors will continue to assess her condition, including other issues associated with her concussion,” Clinton spokesman Philippe Reines said in a statement. “They will determine if any further action is required.”


The State Department had said earlier that Clinton was set to resume her normal office schedule this week.


Earlier this month, the former first lady and New York senator had cited her concussion in canceling her scheduled appearance before a congressional committee investigating the Sept. 11 attack on a U.S. diplomatic facility in Benghazi, Libya, that left four Americans dead, including the ambassador.


A separate high-level investigative panel issued a scathing report blaming the State Department for security lapses. Clinton took responsibility, writing to the congressional committee that she  accepted "every one" of the Accountability Review Board's 29 recommendations.


She also praised the board, saying it had offered "a clear-eyed look at serious, systematic challenges that we have already begun to fix." 


Some conservatives had accused her of faking her illness to avoid testifying before the committee -- an accusation that the State Department strenuously denied. 









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Kobe Bryant Finally Joins Twitter — Kind Of






Long among the sports world’s biggest Twitter holdouts, Kobe Bryant has finally joined the social network. But he hasn’t opened an account, and won’t be around for long.


Social savvy fans are being blessed with his presence thanks to Nike Basketball, which has turned over its account to Bryant since Tuesday.






[More from Mashable: Avery Johnson’s Teenage Son Unloads on Twitter After NBA Firing]


Nike Basketball, which sponsors Bryant and produces his official sneaker, announced the Kobe takeover in a Christmas Day tweet. The account’s name is now “Kobe Bryant” although its handle remains @nikebasketball. Kobe has spent the past few days tweeting about a variety of subjects using a series of hashtags that play off the theme #counton-fill-in-the-blank.


He’s tweeted about the Lakers progress as a team:


[More from Mashable: FanDuel Is Fantasy Sports With a Twist]


He’s tweeted behind-the-scenes snippets of training and treatment:


And he’s tweeted a totally normal, typical, everyday holiday family portrait:


Bryant actually joined Twitter for realsies back in 2011, but then deleted the account after racking up more than 35,000 followers in a just a few hours. He’s one of the NBA’s few stars without a Twitter presence. Nearly 90% of the league’s players are on the social network, according to Twitter.


But Bryant did become much more active on Facebook this summer, especially while traveling with the United States’ Olympic basketball team. He has nearly 15 million fans there, and reportedly writes his status updates and messages himself, with editing and actual posting done by support staff. In November he asked Facebook fans whether to join Instagram or Twitter next, and on Monday hinted in a status update that he may soon open an Instagram account.


What athletes would you most like to see get more active on social media? Let us know in the comments.


BONUS: 30 Must-Follow Twitter Accounts This NBA SEASON


1. @NBA


The NBA is arguably the world’s most engaging sports league on social media. Follow its official Twitter account for news, highlights and promotions.


Click here to view this gallery.


Thumbnail image courtesy Flickr, Keith Allison


This story originally published on Mashable here.


Social Media News Headlines – Yahoo! News





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'The Hobbit' stays atop box office for third week


LOS ANGELES (AP) — "The Hobbit: An Unexpected Journey" continues to rule them all at the box office, staying on top for a third-straight week and capping a record-setting $10.8 billion year in moviegoing.


The Warner Bros. fantasy epic from director Peter Jackson, based on the beloved J.R.R. Tolkien novel, made nearly $33 million this weekend, according to Sunday studio estimates, despite serious competition from some much-anticipated newcomers. It's now made a whopping $686.7 million worldwide and $222.7 million domestically alone.


Two big holiday movies — and potential Academy Awards contenders — also had strong openings. Quentin Tarantino's spaghetti Western-blaxploitation mash-up "Django Unchained" came in second place for the weekend with $30.7 million. The Weinstein Co. revenge comedy, starring Jamie Foxx as a slave in the Civil War South and Christoph Waltz as the bounty hunter who frees him and then makes him his partner, has earned $64 million since its Christmas Day opening.


And in third place with $28 million was the sweeping, all-singing "Les Miserables," based on the international musical sensation and the Victor Hugo novel of strife and uprising in 19th century France. The Universal Pictures film, with a cast of A-list actors singing live on camera led by Hugh Jackman, Anne Hathaway and Russell Crowe has made $67.5 million domestically and $116.2 worldwide since debuting on Christmas.


Additionally, the smash-hit James Bond adventure "Skyfall" has now made $1 billion internationally to become the most successful film yet in the 50-year franchise, Sony Pictures announced Sunday. The film stars Daniel Craig for the third time as the iconic British superspy.


"This is a great final weekend of the year," said Paul Dergarabedian, an analyst for box-office tracker Hollywood.com. "How perfect to end this year on such a strong note with the top five films performing incredibly well."


The week's other new wide release, the Billy Crystal-Bette Midler comedy "Parental Guidance" from 20th Century Fox, made $14.8 million over the weekend for fourth place and $29.6 million total since opening on Christmas.


Dergarabedian described the holding power of "The Hobbit" in its third week as "just amazing." Jackson shot the film, the first of three prequels to his massively successful "Lord of the Rings" series, in 48 frames per second — double the normal frame rate — for a crisper, more detailed image. It's also available in the usual 24 frames per second and both 2-D and 3-D projections.


"I think people are catching up with the movie. Maybe they're seeing it in multiple formats," he said. "I think it's just a big epic that feels like a great way to end the moviegoing year. There's momentum there with this movie."


"Django Unchained" is just as much of an epic in its own stylishly violent way that's quintessentially Tarantino. Erik Lomis, The Weinstein Co.'s president of theatrical distribution, said the opening exceeded the studio's expectations.


"We're thrilled with it, clearly. We knew it was extremely competitive at Christmas, particularly when you look at the start 'Les Miz' got. We were sort of resigned to being behind them. The fact that we were able to overtake them over the weekend was just great," Lomis said. "Taking nothing away from their number, it's a tribute to the playability of 'Django.'"


"Les Miserables" went into its opening weekend with nearly $40 million in North American grosses, including $18.2 on Christmas Day. That's the second-best opening ever on the holiday following "Sherlock Holmes," which made $24.9 million on Christmas 2009. Tom Hooper, in a follow-up to his Oscar-winner "The King's Speech," directs an enormous, ambitious take on the beloved musical which has earned a CinemaScore of "A'' from audiences and "A-plus" from women.


Nikki Rocco, Universal's head of distribution, said the debut for "Les Miserables" also beat the studio's expectations.


"That $18.2 million Christmas Day opening — people were shocked ... This is a musical!" she said. "Once people see it, they talk about how fabulous it is."


It all adds up to a record-setting year at the movies, beating the previous annual record of $10.6 billion set in 2009. Dergarabedian pointed out that the hits came scattered throughout the year, not just during the summer blockbuster season or prestige-picture time at the end. "Contraband," ''Safe House" and "The Vow" all performed well early on, but then when the big movies came, they were huge. "The Avengers" had the biggest opening ever with $207.4 million in May. The raunchy comedy "Ted" and comic-book behemoth "The Dark Knight Rises" both found enormous audiences. And Paul Thomas Anderson's challenging drama "The Master" shattered records in September when it opened on five screens in New York and Los Angeles with $736,311, for a staggering per-screen average of $147,262.


"We were able to get this record without scratching and clawing to a record," he said.


Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are also included. Final domestic figures will be released Monday.


1. "The Hobbit: An Unexpected Journey," $32.9 million ($106.5 million international).


2."Django Unchained," $30.7 million.


3."Les Miserables," $28 million ($38.3 million international).


4."Parental Guidance," $14.8 million ($7 million international).


5."Jack Reacher," $14 million ($18.1 million).


6."This Is 40," $13.2 million.


7."Lincoln," $7.5 million.


8."The Guilt Trip," $6.7 million.


9."Monsters, Inc. 3-D," $6.4 million.


10."Rise of the Guardians," $4.9 million ($11.6 million).


___


Estimated weekend ticket sales at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:


1."The Hobbit: An Unexpected Journey," $106.5 million.


2."Life of Pi," $39.2 million.


3."Les Miserables," $38.3 million.


4."Wreck-It Ralph," $20.4 million.


5."Jack Reacher," $18.1 million.


6."Rise of the Guardians," $11.6 million.


7."Parental Guidance," $7 million.


8."The Tower," $6.6 million.


9."Pitch Perfect," $6.2 million.


10."De L'autre Cote Du Periph," $4 million.


___


Online:


http://www.hollywood.com


http://www.rentrak.com


___


Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.


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Dr. Rita Levi-Montalcini, a Revolutionary in the Study of the Brain, Dies at 103


Fabio Campana/European Pressphoto Agency


Rita Levi-Montalcini, the Italian Nobel laureate, in 2007.







Dr. Rita Levi-Montalcini, a Nobel Prize-winning neurologist who discovered critical chemical tools that the body uses to direct cell growth and build nerve networks, opening the way for the study of how those processes can go wrong in diseases like dementia and cancer, died on Sunday at her home in Rome. She was 103.




Her death was announced by Mayor Gianni Alemanno of Rome.


“I don’t use these words easily, but her work revolutionized the study of neural development, from how we think about it to how we intervene,” said Dr. Gerald D. Fishbach, a neuroscientist and professor emeritus at Columbia.


Scientists had virtually no idea how embryo cells built a latticework of intricate connections to other cells when Dr. Levi-Montalcini began studying chicken embryos in the bedroom of her house in Turin, Italy, during World War II. After years of obsessive study, much of it at Washington University in St. Louis with Dr. Viktor Hamburger, she found a protein that, when released by cells, attracted nerve growth from nearby developing cells.


In the early 1950s, she and Dr. Stanley Cohen, a biochemist also at Washington University, isolated and described the chemical, known as nerve growth factor — and in the process altered the study of cell growth and development. Scientists soon realized that the protein gave them a new way to study and understand disorders of neural growth, like cancer, or of degeneration, like Alzheimer’s disease, and to potentially develop therapies.


In the years after the discovery, Dr. Levi-Montalcini, Dr. Cohen and others described a large family of such growth-promoting agents, each of which worked to regulate the growth of specific cells. One, called epidermal growth factor and discovered by Dr. Cohen, plays a central role in breast cancer; in part by studying its behavior, scientists developed drugs to combat the abnormal growth.


In 1986, Dr. Levi-Montalcini and Dr. Cohen shared the Nobel Prize in Physiology or Medicine for their work.


Dr. Cohen, now an emeritus professor at Vanderbilt University, said Dr. Levi-Montalcini possessed a rare combination of intuition and passion, as well as biological knowledge. “She had this feeling for what was happening biologically,” he said. “She was an intuitive observer, and she saw that something was making these nerve connections grow and was determined to find out what it was.”


One of four children, Rita Levi-Montalcini was born in Turin on April 22, 1909, to Adamo Levi, an engineer, and Adele Montalcini, a painter, both Italian Jews who traced their roots to the Roman Empire. In keeping with the Victorian customs of the time, Mr. Levi discouraged his three daughters from entering college, fearing that it would interfere with their lives as wives and mothers.


It was not a future that Rita wanted. She had decided to become a doctor and told her father so. “He listened, looking at me with that serious and penetrating gaze of his that caused me such trepidation,” she wrote in her autobiography, “In Praise of Imperfection” (1988). He also agreed to support her.


She graduated summa cum laude from the University of Turin medical school in 1936. Two years later, Mussolini issued a manifesto barring non-Aryan Italians from having professional careers. She began her research anyway, setting up a small laboratory in her home to study chick embryos, inspired by the work of Dr. Hamburger, a prominent researcher in St. Louis who also worked with the embryos.


During World War II, the family fled Turin for the countryside, and in 1943 the invasion by Germany forced them to Florence. The family returned at the close of the war, in 1945, and Dr. Hamburger soon invited Dr. Levi-Montalcini to work for a year in his lab at Washington University.


She stayed on, becoming an associate professor in 1956 and a full professor in 1958. In 1962, she helped establish the Institute of Cell Biology in Rome and became its first director. She retired from Washington University in 1977, becoming a guest professor and splitting her time between Rome and St. Louis.


Italy honored her in 2001 by making her a senator for life.


An elegant presence, confident and passionate, she was a sought-after speaker until late in life. “At 100, I have a mind that is superior — thanks to experience — than when I was 20,” she said in 2009.


She never married and had no children. In addition to her autobiography, she was the author or co-author of dozens of research studies and received numerous professional awards, including the National Medal of Science.


“It is imperfection — not perfection — that is the end result of the program written into that formidably complex engine that is the human brain,” Dr. Levi-Montalcini wrote in her autobiography, “and of the influences exerted upon us by the environment and whoever takes care of us during the long years of our physical, psychological and intellectual development.”


This article has been revised to reflect the following correction:

Correction: December 30, 2012

An earlier version of this obituary misstated the year Mussolini issued a manifesto barring non-Aryan Italians from having professional careers. It was 1938, not 1936.



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Champagne sales lose fizz in Europe









Champagne sales are on the wane in economically troubled Europe, but other markets — particularly Japan and the United States — are developing more fondness for the bubbly.

In what is certain to be bad news for the vineyards, France — Champagne's largest market — is drinking fewer bottles. Sales of Champagne for the country were down 4.9%, and 5% elsewhere in the 27-country European Union, in the first nine months of 2012 compared with the same period in 2011, according to CIVC, the national association of growers and producers of the wine.

Nineteen months of rising unemployment and growing fears that the worst is yet to come have taken their toll on France — nearly 7 in 10 French are worried about their country's future, according to a recent poll.





"The French are pessimist by nature," said Antoine Chiquet, whose family has been producing Champagne for three generations and wine for eight. "We had a difficult election, we're in an economy where Europe's foundations are being questioned."

Nonetheless, the country managed to drink 175.7 million bottles of Champagne from Nov. 1, 2011, to Oct. 31, 2012, according to CIVC — nearly three bottles a year for every man, woman and child but about 10 million bottles fewer than the previous year. In contrast, the U.S. consumed enough sparkling wine for about 1.5 bottles per person in 2010, the latest figures available from the Wine Institute in California.

Although the news out of France and Europe is bad, CIVC figures show export sales were up 3% in the first three quarters of the year. Top markets included the U.S., Japan and, to a lesser extent, China. A total of 19.4 million bottles of Champagne went to the United States and 7.9 million went to Japan — the only two countries outside Europe in the top seven export markets.

Takayasu Ogata, a sommelier in Tokyo, said Champagne and sparkling wine consumption is climbing in Japan at a time when overall wine demand peaked around 2000.

"Both individuals and restaurants are taking to Champagnes with personality, including those that are from small makers but taste good," he said.

Lower price is another reason. Gone are the days when a bottle of Moet & Chandon went for $60 or more in Japan. These days, you can get real Champagne for as little as $25.

Of course, for those with rich tastes and a budget to match there are still lots of expensive Champagnes, selling for 10 times that, said Ogata, who is in charge of wines at Venture Republic, an Internet retailer.

Beer remains the drink of choice for many "salarymen," but younger people and women are taking a liking to Champagne, Ogata says.

"It's about the bubble — a sense of gorgeousness," he said in a telephone interview. "There's that thrill to opening up a bottle of Champagne."

China is also emerging as a potentially strong market for a glass of fizz, although the numbers remain small. In 2011, the latest year for which figures were available, it ranked 19th in export markets for Champagne, apparently because consumers are less discriminating about precise origins. According to an EU ruling, only sparkling wine made in a particular region in northeast France is allowed to carry the name Champagne. The United States makes some exceptions, as long as the labeling is clear.

"People enjoy the 'boom' moment of opening sparkling wine. It is fun," said Yu Ming, a 29-year-old who operated a bar in Beijing's Sanlitun night-life district until 2010. "It offers a more festive atmosphere and it tastes good." In China, he added, "people call all sparkling wine Champagne. They don't care where it is from or whether the fermentation is inside the bottle."

The sales manager at the BHG supermarket in a luxury shopping mall in Beijing confirmed that Champagne budgets are largely out of reach in China, saying most customers at the chic store will instead choose sparkling wine: "The most expensive Champagne is 7,800 yuan [$1,250] a bottle at my store, but the most expensive sparkling wine is only 268 yuan [$43]," said the manager, who gave his surname, Hou.

Chiquet, whose label Gaston Chiquet produces about 200,000 bottles a year, said France and Europe generally will remain the most important markets for Champagne. But for the numbers to climb again "we'll have to rediscover optimism."

"Champagne remains a drink for celebrating the big events of life," Chiquet said. "Happily for sales, at the end of the year, the French rely on tradition. Still, we're not going to catch up. Unfortunately, what's lost already is lost."





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